Xiangning Xue



Hello and welcome to my homepage! My name is Xiangning Xue and I am a fourth-year PhD candidate in biostatistics at the University of Pittsburgh. My research interests include statistical genomics, circadian analysis, clustering, and Bayesian data analysis. My advisor is George Tseng, a leading expert in these fields. I am passionate about using data and advanced statistical techniques to better understand biological systems and improve human health. Following is a word cloud generated from my published papers and distinguished papers from my research area (tool link).



Education

  • PhD in Biostatistics, University of Pittsburgh (2019-2024)
  • Master of Public Health in Biostatistics, Emory University (2017-2019)
  • Bachelor of Science in Marine Biology, Xiamen University (2012-2016)

Researches

  • Pipeline development for differential rhythmicity analysis
  • Bayesian modeling for meta-rhythmicity-analysis
  • Semi-supervised learning model for count data

Collaborations

  • Analyses of the differential effects of psychiatric diseases on circadian rhythms in multiple brain regions.
  • Investigating the molecular mechanisms underlying treatment response in late-life depression.
  • Treatment response prediction for depressed participants using baseline biomarke
  • A meta-analysis of first-episode psychosis studies and central insulin studies to identify the mechanisms behind psychosis-related metabolic abnormalities.
  • Comparison of cell subtyping methods for Cytometry data.
  • Cytokine correlation analysis in depression disorder in both human and mice.
  • Transcriptional alternation analysis of subjects with opioid use disorder

Teaching

Teaching Assistant at Department of Biostatistics, University of Pittsburgh

(Aug. 2021 − Dec. 2021)

  • TA for BIOST 2069 - Statistical Methods for Omics Data.
  • Designed and teached the lab session, designed and graded student homework, offered support during office hours.
  • Received positive feedbacks from students.

Publications (Google Scholar)

  • Xue, X., Zong, W., Huo Z., K. Ketchesin, Scott M., Petersen K., Logan R., Seney M., McClung C., Tseng G. (2023+). DiffCircaPipeline: A framework for multifaceted characterization of differential rhythmicity. Bioinformatics (Under Revision).
  • Xue, X., Zong, W., Glausier, J. R., Kim, S. M., Shelton, M. A., Phan, B. N., … & Logan, R. W. (2022). Molecular rhythm alterations in prefrontal cortex and nucleus accumbens associated with opioid use disorder. Translational Psychiatry, 12(1), 1-13.
  • Logan, R. W., Xue, X., Ketchesin, K. D., Hoffman, G., Roussos, P., Tseng, G., … & Seney, M. L. (2022). Sex differences in molecular rhythms in the human cortex. Biological Psychiatry, 91(1), 152-162.
  • Seney, M. L., Kim, S. M., Glausier, J. R., Hildebrand, M. A., Xue, X., Zong, W., … & Logan, R. W. (2021). Transcriptional alterations in dorsolateral prefrontal cortex and nucleus accumbens implicate neuroinflammation and synaptic remodeling in opioid use disorder. Biological Psychiatry, 90(8), 550-562.
  • Barko, K., Shelton, M., Xue, X., Afriyie-Agyemang, Y., Puig, S., Freyberg, Z., … & Seney, M. L. (2022). Brain region-and sex-specific transcriptional profiles of microglia. Frontiers in psychiatry, 1749.
  • Peng Liu, Silvia Liu, Yusi Fang, Xiangning Xue, Jian Zou, George Tseng, Liza Konnikova. (2020) Recent Advances in Computer-assisted Algorithms for Cell Subtype Identification of Cytometry Data. Frontiers in Cell and Developmental Biology. 8:234.
  • Aslanoglou, D., Bertera, S., Friggeri, L., Sánchez-Soto, M., Lee, J., Xue, X., … & Freyberg, Z. (2022). Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine. Iscience, 25(8), 104771.
  • Logan, R. W., Ozburn, A. R., Arey, R. N., Ketchesin, K. D., Winquist, A., Crain, A., Tobe B. T. D., Becker-Krail D., Jarpe M. B., Xue, X., … & McClung, C. A. (2021). Valproate reverses mania-like behaviors in mice via preferential targeting of HDAC2. Molecular psychiatry, 26(8), 4066-4084.
  • Aslanoglou, D., Bertera, S., Sánchez-Soto, M., Benjamin Free, R., Lee, J., Zong, W., Xue, X.,… & Freyberg, Z. (2021). Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors. Translational psychiatry, 11(1), 1-18.