Xiangning Xue
Hello and welcome to my homepage! My name is Xiangning Xue and I am a
fourth-year PhD candidate in biostatistics at the University of
Pittsburgh. My research interests include statistical genomics,
circadian analysis, clustering, and Bayesian data analysis. My advisor
is George Tseng, a leading expert in these fields. I am passionate about
using data and advanced statistical techniques to better understand
biological systems and improve human health. Following is a word cloud
generated from my published papers and distinguished papers from my
research area (tool
link).
Education
- PhD in Biostatistics, University of Pittsburgh (2019-2024)
- Master of Public Health in Biostatistics, Emory University
(2017-2019)
- Bachelor of Science in Marine Biology, Xiamen University
(2012-2016)
Researches
- Pipeline development for differential rhythmicity analysis
- Bayesian modeling for meta-rhythmicity-analysis
- Semi-supervised learning model for count data
Collaborations
- Analyses of the differential effects of psychiatric diseases on
circadian rhythms in multiple brain regions.
- Investigating the molecular mechanisms underlying treatment response
in late-life depression.
- Treatment response prediction for depressed participants using
baseline biomarke
- A meta-analysis of first-episode psychosis studies and central
insulin studies to identify the mechanisms behind psychosis-related
metabolic abnormalities.
- Comparison of cell subtyping methods for Cytometry data.
- Cytokine correlation analysis in depression disorder in both human
and mice.
- Transcriptional alternation analysis of subjects with opioid use
disorder
Teaching
Teaching Assistant at Department of Biostatistics, University of
Pittsburgh
(Aug. 2021 − Dec. 2021)
- TA for BIOST 2069 - Statistical Methods for Omics Data.
- Designed and teached the lab session, designed and graded student
homework, offered support during office hours.
- Received positive feedbacks from students.
- Xue, X., Zong, W., Huo Z., K. Ketchesin, Scott M.,
Petersen K., Logan R., Seney M., McClung C., Tseng G. (2023+).
DiffCircaPipeline: A framework for multifaceted characterization of
differential rhythmicity. Bioinformatics (Under Revision).
- Xue, X., Zong, W., Glausier, J. R., Kim, S. M.,
Shelton, M. A., Phan, B. N., … & Logan, R. W. (2022). Molecular
rhythm alterations in prefrontal cortex and nucleus accumbens associated
with opioid use disorder. Translational Psychiatry, 12(1), 1-13.
- Logan, R. W., Xue, X., Ketchesin, K. D., Hoffman,
G., Roussos, P., Tseng, G., … & Seney, M. L. (2022). Sex differences
in molecular rhythms in the human cortex. Biological Psychiatry, 91(1),
152-162.
- Seney, M. L., Kim, S. M., Glausier, J. R., Hildebrand, M. A.,
Xue, X., Zong, W., … & Logan, R. W. (2021).
Transcriptional alterations in dorsolateral prefrontal cortex and
nucleus accumbens implicate neuroinflammation and synaptic remodeling in
opioid use disorder. Biological Psychiatry, 90(8), 550-562.
- Barko, K., Shelton, M., Xue, X., Afriyie-Agyemang,
Y., Puig, S., Freyberg, Z., … & Seney, M. L. (2022). Brain
region-and sex-specific transcriptional profiles of microglia. Frontiers
in psychiatry, 1749.
- Peng Liu, Silvia Liu, Yusi Fang, Xiangning Xue,
Jian Zou, George Tseng, Liza Konnikova. (2020) Recent Advances in
Computer-assisted Algorithms for Cell Subtype Identification of
Cytometry Data. Frontiers in Cell and Developmental Biology. 8:234.
- Aslanoglou, D., Bertera, S., Friggeri, L., Sánchez-Soto, M., Lee,
J., Xue, X., … & Freyberg, Z. (2022). Dual
pancreatic adrenergic and dopaminergic signaling as a therapeutic target
of bromocriptine. Iscience, 25(8), 104771.
- Logan, R. W., Ozburn, A. R., Arey, R. N., Ketchesin, K. D.,
Winquist, A., Crain, A., Tobe B. T. D., Becker-Krail D., Jarpe M. B.,
Xue, X., … & McClung, C. A. (2021). Valproate
reverses mania-like behaviors in mice via preferential targeting of
HDAC2. Molecular psychiatry, 26(8), 4066-4084.
- Aslanoglou, D., Bertera, S., Sánchez-Soto, M., Benjamin Free, R.,
Lee, J., Zong, W., Xue, X.,… & Freyberg, Z. (2021).
Dopamine regulates pancreatic glucagon and insulin secretion via
adrenergic and dopaminergic receptors. Translational psychiatry, 11(1),
1-18.